The overall aim of this work package is to identify the main body systems and modes of toxic effect of ENMs. WP7 will also provide in vivo data on translocation mechanisms and the uptake rates of ENMs for WP9. The work in this work package is carefully coordinated toxic effect of ENMs across a range of organisms from microbes to mammals.

This will provide in vivo- level data for the hazard classification of the ENMs by mode of toxic action on different body systems (e.g. respiratory toxicant, liver toxicity etc.) and by overall magnitude of toxicity (e.g. low toxicity, toxic, very toxic).

This traditional hazard classification approach is intended to provide both the regulatory agencies and industry with information in a format they can use now in their current procedures, and will therefore have high immediate impact.

In parallel, tissue samples from the experiments will be used for state-of- the-art molecular biology in WP10 and WP11 to develop a new systems biology predictive model that will be incorporated into the “ENM safety classifier” in WP12.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

WP7 therefore brings a significant amount of in vivo animal data to the subsequent modelling and predictions.